iORbase: A database for structure and function prediction of insect olfactory receptors
Insects are the most diverse and wildly distributed animals on earth, and vital components of ecosystems, and closely associated with human life. The insect olfactory receptors (iORs) selectively bind to volatile ligands in the environment and affect essential insect behaviors, such as host location, gathering and spawning, communication, foraging, and detecting and evading predators.
iORbase is established as the first platform for the structural and functional analysis of iORs, based on a combined algorithm for gene annotation and protein structure prediction. Moreover, it provides the option to calculate the binding affinities and binding residues between iORs and pheromone molecules by virtual screening of docking. Furthermore, iORbase supports the automatic structural and functional prediction of user-submitted iORs or pheromones.
iORbase contains the well-analyzed results of approximately 6 000 iORs and their 3D protein structures identified from 59 insect species and 2 077 insect pheromones, as well as approximately 12 million pairs of simulated interactions between functional iORs and pheromones. iORbase includes four online modules, iORPDB, iInteraction, iModelTM, and iOdorTool, to easily retrieve and visualize the 3D structures and interactions.
Please Cite:
Li, Q., Zhang, Y. F., Zhang, T. M., Wan, J. H., Zhang, Y. D., Yang, H., Huang, Y., Xu, C., Li, G. and Lu, H. M. (2023) iORbase: a database for the prediction of the structures and functions of insect olfactory receptors. Insect Science, 30: 1245-1254.doi: 10.1111/1744-7917.13162.
The current version of iORbase is v1.1.2.
We recommend you to use Google Chrome, Microsoft Edge and Firefox. Any suggestions or questions about our database are warmly welcome.
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Protein counts of iORs for each insect species in iORbase |
Physicochemical property distribution of the pheromones included in iORbase |
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Designed by Lu H.M. Lab. ©2022 iORbase.